$\frac{\frac{\mathrm{k1c}\mathrm{mapkk}}{1+\frac{\mathrm{Npp}}{\mathrm{kI}}}\frac{M}{\mathrm{km1}}}{1+\frac{M}{\mathrm{km1}}+\frac{\mathrm{Mp}}{\mathrm{km2}}}$ $\frac{\frac{\mathrm{k2c}\mathrm{mapkk}}{1+\frac{\mathrm{Npp}}{\mathrm{kI}}}\frac{\mathrm{Mp}}{\mathrm{km2}}}{1+\frac{M}{\mathrm{km1}}+\frac{\mathrm{Mp}}{\mathrm{km2}}}$ $\frac{\mathrm{k3c}\mathrm{mkp3}\frac{\mathrm{Mpp}}{\mathrm{km3}}}{1+\frac{\mathrm{Mpp}}{\mathrm{km3}}+\frac{\mathrm{Mp}}{\mathrm{km4}}+\frac{M}{\mathrm{km5}}}$ $\frac{\mathrm{k4c}\mathrm{mkp3}\frac{\mathrm{Mp}}{\mathrm{km4}}}{1+\frac{\mathrm{Mpp}}{\mathrm{km3}}+\frac{\mathrm{Mp}}{\mathrm{km4}}+\frac{M}{\mathrm{km5}}}$ $\frac{\mathrm{k1c}\mathrm{Mpp}\mathrm{kI2}\frac{N}{\mathrm{km1}}}{1+\frac{N}{\mathrm{km1}}+\frac{\mathrm{Np}}{\mathrm{km2}}}$ $\frac{\mathrm{k2c}\mathrm{Mpp}\mathrm{kI2}\frac{\mathrm{Np}}{\mathrm{km2}}}{1+\frac{N}{\mathrm{km1}}+\frac{\mathrm{Np}}{\mathrm{km2}}}$ $\frac{\mathrm{k3c}\mathrm{mkp3}\frac{\mathrm{Npp}}{\mathrm{km3}}}{1+\frac{\mathrm{Npp}}{\mathrm{km3}}+\frac{\mathrm{Np}}{\mathrm{km4}}+\frac{N}{\mathrm{km5}}}$ $\frac{\mathrm{k4c}\mathrm{mkp3}\frac{\mathrm{Np}}{\mathrm{km4}}}{1+\frac{\mathrm{Npp}}{\mathrm{km3}}+\frac{\mathrm{Np}}{\mathrm{km4}}+\frac{N}{\mathrm{km5}}}$